![]() Other studies have shown methylprednisolone was effective in treating dry eye.3 However, this drugs use was limited due to the chronic nature of dry eye and the risk of long-term steroid use. In the study, 83% of patients showed improvements in symptoms after two weeks of steroid use.2 Research shows that T-lymphocytes in the surface epithelial and lacrimal glands of Sjgrens patients and in those with severe dry eye to be 200 to 1,000 times that of normal patients. Recent studies indicate that inflammation is a key component in dry eye. It will not induce brow ache, accommodation or miosis.Īlrex (loteprednol etabonate 0.2%, Bausch & Lomb) has been shown to be an effective treatment for dry eye. So, Alphagan does not affect the ciliary muscle. ![]() Alpha-gan does not affect the parasympa- thetic pathway as pilocarpine does. This causes hyperpolarization and inhibits further norepinephrine release. ![]() The effect occurs through stimulation of the alpha2 receptor that operates the gain-control feedback mechanism of the pupil dilator. The drug also showed a significant decrease in mydriasis in scotopic illumination at precisely when it is needed.ĭata show an average decrease in pupil size of 2mm in dim light after brimonidine use. Unlike pilocarpine, which has many side effects and maintains a miotic pupil in all light, Alphagan maintains a normal pupil in photopic and room illumination. Researchers compared these measurements with those of the patients baseline without the use of Alphagan. Pupil measurements were taken at 30 minutes, and at four and six hours under scotopic, room and photopic illumination. In this study, patients instilled one drop of Alphagan in their eyes. One study showed that Alphagan significantly decreased pupil size under scotopic conditions but not under photopic light.1 Many doctors tell patients to instill one drop 30 minutes before an anticipated need, such as night driving. Two such problemsnight glare after refractive surgery and dry eyehave been the subjects of recent studies into off-label uses.Īlphagan (brimonidine 0.2%, Allergan) has been used for diminishing or eliminating large pupil size related to night vision problems following refractive surgery. Studies into off-label uses of ophthalmic drugs can help us understand options for treating problems we commonly see in practice.
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